THE COMBINED EFFECT OF MARIHUANA AND DEXTROAMPHETAMINE
| Autor: | Louis Lemberger, Robert Martz, M. Evans, Robert B. Forney, Bruce E. Rodda |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Automobile Driving Dextroamphetamine Time Factors Subjective effects Physiology Poison control Motor Activity Locomotor activity General Biochemistry Genetics and Molecular Biology Methamphetamine Mice History and Philosophy of Science Reaction Time Animals Humans Medicine Drug Interactions Dronabinol Young adult Cannabis Psychomotor learning biology business.industry General Neuroscience Hemodynamics biology.organism_classification Blood pressure Motor Skills business medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 281:162-170 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1976.tb27928.x |
| Popis: | The studies in mice indicated that locomotor activity could be stimulated THC and that this would enhance the effect produced by MAMP. We have previously shown that when 3, 6, or 9 mug/kg THC were administered to young adult males by MJ smoking, a dose-related impairment in standing steadiness (WB) and attentive motor performance (PM) resulted, although DAF and subjective evaluations were insensitive to these treatments. These same testing procedures after d-AMP 5, 10, and 15 mg/70 kg revealed no important performance effect. Systolic blood pressure was elevated with 15 mg/70 kg d-AMP, and subjective detection was positive and dose related. A combination of 25 mug/kg THC delivered by smoking an appropriate MJ cigarette and 10 mg/70 kd d-AMP taken orally produced subjective effects and psychomotor performance decrements not different from those with the MJ alone. The doses used were modest, yet most subjects believed their driving performance, a representative motor and metal skill, would be impaired. This judgment is supported by the laboratory measurements made. It is reasonable that realistically higher doses may not only have adverse psychological and cardiovascular effects but increase an accident potential. Language: en |
| Databáze: | OpenAIRE |
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