Bone-Targeted Nanoplatform Combining Zoledronate and Photothermal Therapy To Treat Breast Cancer Bone Metastasis
| Autor: | Guoqiang Zhou, Xing-Jie Liang, Xinjian Yang, Yu Han, Haisong Zhang, Jinchao Zhang, Dandan Liu, Wentong Sun, Huifang Liu, Yan Jin, Kun Ge |
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| Rok vydání: | 2019 |
| Předmět: |
Surface Properties
Mice Nude General Physics and Astronomy Antineoplastic Agents Apoptosis Bone Neoplasms Breast Neoplasms 02 engineering and technology 010402 general chemistry Zoledronic Acid 01 natural sciences Bone resorption Mice Drug Delivery Systems Breast cancer Osteoclast 3T3-L1 Cells Tumor Cells Cultured Tumor Microenvironment medicine Animals Humans General Materials Science Particle Size Cell Proliferation Mice Inbred ICR business.industry Optical Imaging General Engineering Bone metastasis Cancer Osteoblast Neoplasms Experimental Phototherapy 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences medicine.anatomical_structure Zoledronic acid Cancer cell Cancer research Nanoparticles Drug Screening Assays Antitumor 0210 nano-technology business Porosity medicine.drug |
| Zdroj: | ACS Nano. 13:7556-7567 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.9b00097 |
| Popis: | Bone metastasis, a clinical complication of patients with advanced breast cancer, seriously reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus on inhibiting the cancer cell growth and the osteoclast activity through combination therapy. Therefore, it could be beneficial to develop a bone-targeted drug delivery system to treat bone metastasis. Here, a bone-targeted nanoplatform was developed using gold nanorods enclosed inside mesoporous silica nanoparticles (Au@MSNs) which were then conjugated with zoledronic acid (ZOL). The nanoparticles (Au@MSNs-ZOL) not only showed bone-targeting ability in vivo but also inhibited the formation of osteoclast-like cells and promoted osteoblast differentiation in vitro. The combination of Au@MSNs-ZOL and photothermal therapy (PTT), triggered by near-infrared irradiation, inhibited tumor growth both in vitro and in vivo and relieved pain and bone resorption in vivo by inducing apoptosis in cancer cells and improving the bone microenvironment. This single nanoplatform combines ZOL and PTT to provide an exciting strategy for treating breast cancer bone metastasis. |
| Databáze: | OpenAIRE |
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