INDUCED IMMUNOGLOBULIN SECRETION BY T-CELL-REPLACING PRODUCTS FROM BLUNT TRAUMA PATIENTS
| Autor: | Murray J. Girotti, B. G. Sparkes, J. A. Teodorczyk-Injeyan |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Staphylococcus aureus T-Lymphocytes T cell Lymphocyte Immunoglobulins Wounds Nonpenetrating Critical Care and Intensive Care Medicine Immunoglobulin E Immunoglobulin secretion Biological Factors Pregnancy Humans Medicine Secretion Phytohemagglutinins Cells Cultured B-Lymphocytes biology business.industry T-cell receptor Middle Aged Pathophysiology medicine.anatomical_structure Immunoglobulin M Pokeweed Mitogens Immunoglobulin G Immunology biology.protein Female Surgery Antibody business |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 33:171-178 |
| ISSN: | 0022-5282 |
| DOI: | 10.1097/00005373-199208000-00002 |
| Popis: | The capacity to induce immunoglobulin (Ig) secretion by soluble T-cell-replacing (TCR) factors derived from alloantigen-stimulated T lymphocytes of blunt trauma patients (n = 15, mean ISS = 24) was examined in Staphylococcus aureus (SAC)-activated normal B-cell cultures. The majority of the patients studied demonstrated a profound suppression of the T-cell-dependent, pokeweed-mitogen-induced Ig production. However, the activity to induce Ig secretion associated with TCRs from the same patients was not reduced compared with that of TCRs from normal subjects. IgM synthesis was normal and IgG secretion induced by TCRs was within the control range (in 6 of 15 patients) or significantly higher (p less than 0.05) than that in the remaining patients. Both patient-derived and control TCRs failed to induce Ig synthesis in cultures of resting B cells and had comparable mitogenic effects on normal SAC-activated and phytohemagglutinin A-activated B and T lymphocytes, respectively. Thus, the intrinsic ability of T lymphocytes to produce B-cell helper factors appears to be unaffected following blunt trauma. Suppression of the T-cell-regulated Ig secretion in traumatized patients may therefore reflect an altered B lymphocyte response to such factors. |
| Databáze: | OpenAIRE |
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