Time-dependent physiological regulation of ovine placental GLUT-3 glucose transporter protein
| Autor: | William W. Hay, Utpala G. Das, Sherin U. Devaskar, RA Ehrhardt, Jing He |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
endocrine system medicine.medical_specialty Monosaccharide Transport Proteins endocrine system diseases Physiology Placenta Glucose uptake Nerve Tissue Proteins Hypoglycemia Biology Pregnancy Fetal membrane Physiology (medical) Internal medicine medicine Animals Homeostasis Maternal-Fetal Exchange Fetus Sheep Glucose Transporter Type 3 Glucose transporter nutritional and metabolic diseases Fetal Blood medicine.disease Epithelium Pregnancy Complications carbohydrates (lipids) Endocrinology medicine.anatomical_structure Hyperglycemia Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 279:R2252-R2261 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.2000.279.6.r2252 |
| Popis: | We immunolocalized the GLUT-3 glucose transporter isoform versus GLUT-1 in the late-gestation epitheliochorial ovine placenta, and we examined the effect of chronic maternal hyperglycemia and hypoglycemia on placental GLUT-3 concentrations. GLUT-3 was limited to the apical surface of the trophoectoderm, whereas GLUT-1 was on the basolateral and apical surfaces of this cell layer and in the epithelial cells lining the placental uterine glands. GLUT-3 concentrations declined at 17–20 days of chronic hyperglycemia ( P < 0.05), associated with increased uterine and uteroplacental net glucose uptake rate, but a normal fetal glucose uptake rate was observed. Chronic hypoglycemia did not change GLUT-3 concentrations, although uterine, uteroplacental, and fetal net glucose uptake rates were decreased. Thus maternal hyperglycemia causes a time-dependent decline in the entire placental glucose transporter pool (GLUT-1 and GLUT-3). In contrast, maternal hypoglycemia decreases GLUT-1 but not GLUT-3, resulting in a relatively increased GLUT-3 contribution to the placental glucose transporter pool, which could maintain glucose delivery to the placenta relative to the fetus when maternal glucose is low. |
| Databáze: | OpenAIRE |
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