Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
| Autor: | Janet Austin, Stuart Liddle, Louise Cadman, Pat Soutter, Roberto Dina, George Terry, Christine Bergeron, Julie McCarthy, Jack Cuzick, Anne Szarewski, L. Ambroisine, Deirdre Lyons, Hilary Buckley, Linda Ho |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Epidemiology Population Cervical intraepithelial neoplasia Gastroenterology Sensitivity and Specificity Predictive Value of Tests Internal medicine Cytology Biopsy medicine Humans Papillomaviridae education Oligonucleotide Array Sequence Analysis Colposcopy Gynecology Vaginal Smears education.field_of_study medicine.diagnostic_test biology business.industry Papillomavirus Infections Nucleic Acid Hybridization biology.organism_classification medicine.disease Uterine Cervical Dysplasia Immunohistochemistry female genital diseases and pregnancy complications Oncology ROC Curve Predictive value of tests High Grade Cervical Intraepithelial Neoplasia DNA Viral Female business |
| Zdroj: | Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 17(11) |
| ISSN: | 1055-9965 |
| Popis: | Background: The detection of high-risk human papillomavirus (HPV) DNA provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN). This study compared the sensitivity and specificity of several adjunctive tests for the detection of high-grade CIN in a population referred to colposcopy because of abnormal cytology. Methods: 953 women participated in the study. Up to seven tests were carried out on a liquid PreservCyt sample: Hybrid Capture II (Digene), Amplicor (Roche), PreTect HPV-Proofer (NorChip), APTIMA HPV assay (Gen-Probe), Linear Array (Roche), Clinical-Arrays (Genomica), and CINtec p16INK4a Cytology (mtm Laboratories) immunocytochemistry. Sensitivity, specificity, and positive predictive value (PPV) were based on the worst histology seen on either the biopsy or the treatment specimen after central review. Results: 273 (28.6%) women had high-grade disease (CIN2+) on worst histology, with 193 (20.2%) having CIN3+. For the detection of CIN2+, Hybrid Capture II had a sensitivity of 99.6%, specificity of 28.4%, and PPV of 36.1%. Amplicor had a sensitivity of 98.9%, specificity of 21.7%, and PPV of 33.5%. PreTect HPV-Proofer had a sensitivity of 73.6%, specificity of 73.1%, and PPV of 52.0%. APTIMA had a sensitivity of 95.2%, specificity of 42.2%, and PPV of 39.9%. CINtec p16INK4a Cytology had a sensitivity of 83.0%, specificity of 68.7%, and PPV of 52.3%. Linear Array had a sensitivity of 98.2%, specificity of 32.8%, and PPV of 37.7%. Clinical-Arrays had a sensitivity of 80.9%, specificity of 37.1%, and PPV of 33.0%. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3033–42) |
| Databáze: | OpenAIRE |
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