Quantitative analysis of enantioselective enzymatic hydrolysis with non-enantioselective removal of chiral products

Autor:	S.W. Tsai, I.C. Cheng
Rok vydání:	2000
Předmět:	Environmental Engineering Chemistry organic chemicals Biomedical Engineering Enantioselective synthesis Bioengineering Pyrrolidine Kinetic resolution Hydrolysis chemistry.chemical_compound Enzymatic hydrolysis Organic chemistry Enantiomer Enantiomeric excess Chiral derivatizing agent Biotechnology
Zdroj:	Biochemical engineering journal. 5(3)
ISSN:	1369-703X
Popis:	Kinetic resolution of racemic compounds by enzymatic hydrolysis with non-enantioselective separation of enantiomer products via a separator or ion-pair formation has been quantitatively analyzed. Theoretical results indicate that the removal of chiral products has profound effects on improving the conversion and enantiomeric excess for the desired chiral substrate or product. The analysis was confirmed from lipase-catalyzed hydrolysis of racemic methyl 2-chloropropionate in the presence of pyrrolidine in buffer saturated dichloromethane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe839f3d3262b8ffb28fa1207cfab8f https://pubmed.ncbi.nlm.nih.gov/10828426 Zobrazit plný text záznamu Full Text from ScienceDirect