The Number and Proportion of V 9V 2 T Cells Rise Significantly in the Peripheral Blood of Patients After the Onset of Acute Coxiella burnetii Infection
| Autor: | Martin Zeitz, Dagmar Steinhoff, Ernst-Otto Riecken, Jahn Hu, Reiner Ullrich, T Schneider, Oliver Liesenfeld |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Microbiology (medical) T cell chemical and pharmacologic phenomena Q fever Immune system T-Lymphocyte Subsets medicine Humans IL-2 receptor Aged biology business.industry Respiratory disease Receptors Antigen T-Cell gamma-delta hemic and immune systems HLA-DR Antigens T lymphocyte biology.organism_classification Coxiella burnetii medicine.disease stomatognathic diseases Infectious Diseases medicine.anatomical_structure Acute Disease Immunology Female Q Fever Rickettsiales business |
| Zdroj: | Clinical Infectious Diseases. 24:261-264 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/24.2.261 |
| Popis: | We conducted serial studies on peripheral blood lymphocytes from four patients with acute Coxiella burnetii infection. These studies revealed that the proportion of gammadelta T cells in these patients significantly increased after the onset of disease (mean, 16%; range, 13%-30%) as compared with that in five healthy controls (mean, 4%; range, 0.5%-7%; P < .0055) and that in five controls with pneumonia (mean, 2%; range, 1%-3%; P < .0014). Most of the gammadelta T cells from these patients expressed the Vgamma9 Vdelta2 gene product. During the acute phase of disease, most gammadelta T cells expressed the activation marker human leukocyte antigen DR but not CD25. During this phase, gammadelta T cell activation was higher than alphabeta T cell activation. Our findings indicate that gammadelta T cells are predominantly involved in the acute immune response to C. burnetii. |
| Databáze: | OpenAIRE |
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