Functional Capillary Rarefaction in Mild Blood Pressure Elevation
| Autor: | Bonita Falkner, Cynthia Cheng, James J. Diamond |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Black People Blood Pressure Vasodilation Biology White People General Biochemistry Genetics and Molecular Biology Blood pressure elevation Microcirculation Risk Factors Internal medicine Ethnicity medicine Capillary Rarefaction Humans Plethysmograph General Pharmacology Toxicology and Pharmaceutics Endothelial dysfunction Research Articles Microscopy General Neuroscience General Medicine Anatomy Middle Aged medicine.disease Capillaries Blood pressure Capillary density Hypertension Cardiology Female Endothelium Vascular |
| Zdroj: | Clinical and Translational Science. 1:75-79 |
| ISSN: | 1752-8062 1752-8054 |
| Popis: | Capillary rarefaction is described in patients with moderate‐to‐severe hypertension. The study objective was to determine if structural and/or functional capillary rarefaction is detectable and associated with endothelial dysfunction in patients with mild blood pressure elevation (HBP: Systolic blood pressure 130–160 mm Hg). Capillary density was quantified by direct capillaroscopy in 110 nondiabetic black and non‐black subjects. Endothelial function was quantified by plethysmographic measures of flow‐mediated vasodilation. Compared to normotensives (NBP: N = 90), functional capillary rarefaction was detected in HBP (N = 20; p < 0.001). Functional capillary density measures correlated with endothelial function (p < 0.001). Functional, but not structural, capillary rarefaction is detectable and associated with endothelial dysfunction in both black and non‐black individuals with mild blood pressure elevation. |
| Databáze: | OpenAIRE |
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