Low-dose chronic inhalation of diesel exhaust and/or coal dust by rats: Effect of age and exposure on lung and liver cytochrome P-450
| Autor: | Karl J. Marion, Jean Rabovsky, Martin R. Petersen, Robert D. Groseclose, Trent R. Lewis |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Aging Diesel exhaust Health Toxicology and Mutagenesis 7-Alkoxycoumarin O-Dealkylase Toxicology Coal dust complex mixtures Biochemistry Diesel fuel chemistry.chemical_compound Animal science Cytochrome P-450 Enzyme System Air Pollution Microsomes Animals Coal Benzopyrene Hydroxylase Lung Pharmacology Inhalation business.industry technology industry and agriculture Dust General Medicine respiratory system Rats Inbred F344 Rats respiratory tract diseases Petroleum chemistry Toxicity Microsomes Liver Oxygenases Microsome Pyrene business human activities |
| Zdroj: | Xenobiotica. 14:595-598 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498258409151454 |
| Popis: | 1. Rats were exposed by inhalation to low levels of diesel exhaust and/or coal dust, seven hours/day, five days/week for 24 months.2. Cytochrome P-450-associated benzo[a]pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 months.3. When data were analysed across all time intervals and adjusted for age, lower benzo[a]pyrene hydroxylase activity was observed in lung microsomes from rats exposed to diesel exhaust plus coal dust than in those exposed to coal dust alone.4. Data are discussed in terms of (a) interaction between diesel exhaust and coal dust and (b) effect of infectious agents. |
| Databáze: | OpenAIRE |
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