A single dose of l-DOPA changes perceptual experiences and decreases latent inhibition in Parkinson’s disease
| Autor: | Orsolya Györfi, Helga Nagy, Oguz Kelemen, Magdolna Bokor, Szabolcs Kéri |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Psychosis medicine.medical_specialty Parkinson's disease Visual analogue scale Neuropsychological Tests Audiology Dysphoria Psychoses Substance-Induced Antiparkinson Agents Levodopa 03 medical and health sciences 0302 clinical medicine Latent inhibition medicine Humans Attention Psychiatry Biological Psychiatry Dopaminergic Parkinson Disease Middle Aged Psychotomimetic Time perception medicine.disease 030227 psychiatry Inhibition Psychological Psychiatry and Mental health Neurology Female Perception Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neural Transmission. 124:113-119 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-016-1630-6 |
| Popis: | Despite the well-known neuropsychiatric side effects of dopaminergic medications, the possible subjective psychotomimetic effects of a single dose of L-DOPA in newly diagnosed, drug-naïve patients with Parkinson's disease (PD) are not known. To investigate this question, we used a visual search task for latent inhibition (LI), the Community Assessment of Psychic Experiences (CAPE) scale, and visual analog scales for psychotomimetic effects (perception, relaxation, and dysphoria) in 28 de novo PD patients before (off) and after (on) the adminstration of L-DOPA and in 25 matched healthy control individuals. Results revealed increased LI in PD-off and decreased LI in PD-on relative to the control subjects. After the administration of L-DOPA, we observed a significant decline in LI in PD. L-DOPA also enhanced perceptual experiences (changes in subjective feelings in thinking, time perception, and mental "highness"). Greater reduction in LI was associated with enhanced perceptual experiences. These results suggest that a single dose of L-DOPA has a significant psychotomimetic effect, which is associated with decreased LI, a behavioral marker of psychosis-like experiences. |
| Databáze: | OpenAIRE |
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