Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics

Autor: Kazuno Negishi, Hidemasa Torii, Yasuyo Nishi, Kazuo Tsubota, Shirakawa Yoshinori, Yukari Tsuneyoshi, Nishizaki Saori, Yuki Hidaka, Kinoshita Taku, Yoko Arita, Deokho Lee, Ari Shinojima, Kimura Sho, Toshihide Kurihara
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Blood Glucose
Male
Physiology
medicine.medical_treatment
Biochemistry
Endocrinology
Medical Conditions
Glucose Metabolism
Medicine and Health Sciences
Prospective Studies
Prospective cohort study
Glucose dynamics
Aged
80 and over
Multidisciplinary
medicine.diagnostic_test
Organic Compounds
Monosaccharides
Ophthalmic Procedures
Cataract Surgery
Middle Aged
University hospital
Blood Sugar
Body Fluids
Chemistry
Blood
Physical Sciences
Carbohydrate Metabolism
Medicine
Female
Anatomy
Research Article
Anterior Chamber
Endocrine Disorders
Science
Carbohydrates
Blood sugar
Surgical and Invasive Medical Procedures
Cataract Extraction
Ocular System
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Hypoglycemic Agents
Glycemic
Aged
Blood glucose monitoring
business.industry
Blood Glucose Self-Monitoring
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Cataract surgery
medicine.disease
Glucose
Metabolism
Metabolic Disorders
Eyes
business
Head
Zdroj: PLoS ONE, Vol 16, Iss 9, p e0256986 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H2O2-electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.
Databáze: OpenAIRE
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