Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems
| Autor: | Yun Wang, Yu Xu, Qing-Yang Bai, Xiao-Hong Sun, Chen Qi, Na-Xi Tian |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Physiology Inflammatory pain Pain medicine Analgesic Freund's Adjuvant Pain Method Neuropathic pain Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Gait (human) Physical medicine and rehabilitation Image Processing Computer-Assisted Medicine Animals Treadmill Gait Inflammation Analgesics business.industry General Neuroscience General Medicine CatWalk™ DigiGait™ 030104 developmental biology Nociception Gait analysis Neuralgia business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Bulletin |
| ISSN: | 1995-8218 |
| Popis: | Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury: coordination data) and inflammatory pain (intraplantar complete Freund’s adjuvant: both coordination and intensity data) in the DigiGait™ and CatWalk™ systems. DigiGait™ had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk™ excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research. Electronic supplementary material The online version of this article (10.1007/s12264-018-00331-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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