Relationship between plasma levels of sclerostin, calcium-phosphate disturbances, established markers of bone turnover, and inflammation in haemodialysis patients

Autor: Barbara Pietrzyk, Rafał Ficek, Katarzyna Wyskida, Joanna Ficek, Andrzej Wiecek, Magdalena Olszanecka-Glinianowicz, Aureliusz Kolonko, Jerzy Chudek
Rok vydání: 2018
Předmět:
Male
030232 urology & nephrology
030204 cardiovascular system & hematology
Bone remodeling
chemistry.chemical_compound
0302 clinical medicine
Vitamin D
Chronic kidney disease-mineral and bone disorder (CKD-MBD)
biology
Phosphorus
Renal osteodystrophy (ROD)
Middle Aged
Nephrology
Parathyroid Hormone
Bone Morphogenetic Proteins
Osteocalcin
Alkaline phosphatase
Female
Bone Remodeling
Type I collagen
Adult
Genetic Markers
medicine.medical_specialty
Sclerostin
Urology
chemistry.chemical_element
Calcium
vitamin D deficiency
Collagen Type I
Phosphates
03 medical and health sciences
Sex Factors
N-terminal telopeptide
Renal Dialysis
Internal medicine
medicine
Humans
Nephrology - Original Paper
Haemodialysis patients
Adaptor Proteins
Signal Transducing
Aged
Chronic Kidney Disease-Mineral and Bone Disorder
Inflammation
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
medicine.disease
Alkaline Phosphatase
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Endocrinology
chemistry
Calcium–phosphate disturbances
biology.protein
Kidney Failure
Chronic
business
Peptides
Zdroj: International Urology and Nephrology
ISSN: 1573-2584
Popis: Purpose Data concerning the relation between increased levels of circulating sclerostin (a physiological inhibitor of bone formation) and bone turnover in patients with chronic renal failure (CRF) are limited. Therefore, the aim of this study was to evaluate associations between plasma sclerostin levels and calcium–phosphate disturbances, markers of bone turnover as well as inflammation in haemodialysis (HD) patients. Methods In plasma samples obtained in 150 stable HD patients (92 men) aged 40–70 years, levels of sclerostin, fibroblast growth factor (cFGF23), osteocalcin, the N-terminal propeptide of type I procollagen, C-terminal telopeptide of the alpha chain of type I collagen (β-CTx), and inflammatory markers (IL-6 and TNF-α) in addition to routine parameters (calcium, phosphorus, parathyroid hormone—iPTH, 25-OH-D, alkaline phosphatase) were measured. Results Plasma sclerostin concentrations were significantly higher in HD men than women (2.61 vs. 1.88 ng/mL, p
Databáze: OpenAIRE
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