Effects of streptozotocin-induced diabetes on calmodulin and cyclic AMP phosphodiesterase activity in rat lungs
| Autor: | M. S. Nijjar, A. F. Ofulue |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Calmodulin Biology Diabetes Mellitus Experimental Internal medicine Diabetes mellitus medicine Animals Lung Calcium-Binding Proteins Phosphodiesterase Rats Inbred Strains Streptozotocin medicine.disease Cyclic AMP phosphodiesterase activity Rats Subcellular distribution medicine.anatomical_structure Endocrinology 3' 5'-Cyclic-AMP Phosphodiesterases biology.protein Experimental diabetes medicine.drug |
| Zdroj: | Lung. 160(6) |
| ISSN: | 0341-2040 |
| Popis: | Streptozotocin-induced diabetes caused a depression of rat lung tissue cyclic AMP-phosphodiesterase activity. This reduced activity was evident in both the 105,000×g particulate and supernatant fractions prepared from the tissue homogenates. Total calmodulin activity in the lungs from the diabetic rats was also reduced. Calmodulin and phosphodiesterase appeared to be translocated from the particulate to the supernatant fractions during the experimental diabetes. The presence of a heat-stable inhibitor of calmodulin-activated Ca2+-sensitive cyclic AMP-phosphodiesterase was evident in the rat lung and its activity was increased during diabetes. The data suggest that supression of the rat lung cyclic AMP-phosphodiesterase activity during experimental diabetes may result from changes in the subcellular distribution and concentration of the modulators of cyclic AMP-phosphodiesterase in rat lung. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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