Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery
| Autor: | Satoshi Shiono, Makoto Endoh, Katsuyuki Suzuki, Kazuki Hayasaka, Yoshinori Okada |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Nutritional Status 030230 surgery Gastroenterology 03 medical and health sciences Postoperative Complications 0302 clinical medicine Surgical oncology Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Postoperative Period Thoracotomy Aged Lung cancer surgery Lung Receiver operating characteristic business.industry General Medicine Perioperative Middle Aged Prognosis Survival Analysis Cardiac surgery Nutrition Assessment medicine.anatomical_structure ROC Curve Cardiothoracic surgery 030220 oncology & carcinogenesis Female Surgery Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | General Thoracic and Cardiovascular Surgery. 68:1163-1171 |
| ISSN: | 1863-6713 1863-6705 |
| Popis: | The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor. Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. Pre-PNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis. We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (P |
| Databáze: | OpenAIRE |
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