pfk13 -Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

Autor: Julian Muwanguzi, Donelly A. van Schalkwyk, Debbie Nolder, Hayley M. Bennett, Mandy Sanders, Trupti A. Patel, Matthew Berriman, Effrossyni Gkrania-Klotsas, Harparkash Kaur, Peter L. Chiodini, Colin J. Sutherland, Julie Tucker, Thomas D. Otto, Roderick Lynn, Paul Lansdell
Přispěvatelé: Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], Apollo - University of Cambridge Repository
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Artemether/lumefantrine
Drug Resistance
Protozoan Proteins
Gene Expression
Drug resistance
Parasitemia
Treatment failure
0302 clinical medicine
Recurrence
Pharmacology (medical)
Antimalarial Agent
Malaria
Falciparum
Travel
biology
parasite genotyping
Artemisinins
3. Good health
Drug Combinations
Infectious Diseases
Ethanolamines
Female
imported malaria
medicine.drug
medicine.medical_specialty
Plasmodium falciparum
030231 tropical medicine
030106 microbiology
PLASMODIUM FALCIPARUM PARASITEMIA
Clinical Therapeutics
Antimalarials
Young Adult
03 medical and health sciences
Internal medicine
parasitic diseases
medicine
Humans
antimalarial agents
Aged
treatment failure
Pharmacology
Fluorenes
business.industry
Artemether
Lumefantrine Drug Combination
biology.organism_classification
medicine.disease
United Kingdom
drug resistance mechanisms
Genetic Loci
Africa
business
Malaria
Zdroj: Antimicrobial Agents and Chemotherapy
ISSN: 1098-6596
0066-4804
DOI: 10.1128/aac.02382-16
Popis: We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13 -mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
Databáze: OpenAIRE
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