Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study
| Autor: | Jayne Ramshaw, Rodney J. Hicks, Peter Robins, Dishan H. Gunawardana, Ian D. Kirkwood, Joseph C.H. Wong, Andrew M. Scott, Ivan Ho Shon |
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| Rok vydání: | 2008 |
| Předmět: |
Fluorine Radioisotopes
medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Gallium Radioisotopes Scintigraphy Disease-Free Survival Fluorodeoxyglucose F18 immune system diseases hemic and lymphatic diseases Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Gallium Prospective cohort study B-cell lymphoma Neoplasm Staging medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin General Medicine Prognosis medicine.disease Lymphoma Radiation therapy chemistry Positron emission tomography Positron-Emission Tomography Radiology Tomography Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 36:347-353 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-008-0958-z |
| Popis: | Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma. |
| Databáze: | OpenAIRE |
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