Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV
| Autor: | F. Sebag, C. De Micco, R. Giorgi, Jf Henry, Victoria Savchenko |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Thyroid nodules
Cancer Research Pathology medicine.medical_specialty endocrine system Cytodiagnosis Dipeptidyl Peptidase 4 Biopsy Fine-Needle thyroid peroxidase Malignancy Autoantigens Iodide Peroxidase Sensitivity and Specificity Immunoenzyme Techniques Thyroid peroxidase Cytology Iron-Binding Proteins Biopsy Adenocarcinoma Follicular medicine Biomarkers Tumor Humans Thyroid Neoplasms Molecular Diagnostics Hector Battifora mesothelial antigen-1 biology Receiver operating characteristic medicine.diagnostic_test business.industry Thyroid Biopsy Needle medicine.disease Carcinoma Papillary fine-needle aspiration cytology medicine.anatomical_structure dipeptidyl aminopeptidase IV Oncology ROC Curve thyroid nodule biology.protein Adenocarcinoma business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | The purpose of this study was to compare the diagnostic interest of Hector Battifora mesothelial antigen-1 (HBME-1), thyroid peroxidase (TPO), and dipeptidyl aminopeptidase IV (DPP4) in thyroid fine-needle aspirates obtained from 200 resected thyroid lesions (55 colloid nodules, 54 follicular adenomas, 59 papillary cancers, and 32 follicular carcinomas). Hector Battifora mesothelial antigen-1 or TPO expression (% positive cells) and DPP4 staining score (12-point scale) were evaluated. Receiver operating characteristic (ROC) curves were plotted and optimal cutoff values for diagnosing malignancy were determined. The TPO ROC curve was consistently higher than the HBME-1 ROC curve. The TPO curve was also higher than the DPP4 curve with regard to sensitivity, but dipped below the DPP4 curve with regard to specificity. Using a cutoff value of 10% positive cells for HBME-1, and staining score ⩾1 for DPP4, sensitivity to specificity ratios were 98–83% for TPO, 90–60% for HBME-1, and 88–80% for DPP4. Two particularly interesting findings of this study were the low negative likelihood ratio of TPO (0.02) allowing highly reliable exclusion of malignancy and the 100% specificity of DPP4 staining scores=12. Due to poor performance on follicular lesions, HBME-1 showed no advantage over TPO or DPP4. |
| Databáze: | OpenAIRE |
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