Role of the runt‐related transcription factor (RUNX) family in prostate cancer
| Autor: | Devin G. Roller, Sylwia Hasterok, Rosalie Sleppy, Patryk Krakowiak, Hannah Ashe, Daniel Gioeli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Core Binding Factor alpha Subunits medicine.medical_treatment urologic and male genital diseases Biochemistry Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Humans Molecular Biology Transcription factor Tumor microenvironment business.industry Runt Prostatic Neoplasms Androgen Antagonists Cell Biology medicine.disease Androgen receptor Prostatic Neoplasms Castration-Resistant Steroid hormone 030104 developmental biology Receptors Androgen 030220 oncology & carcinogenesis Cancer research business Transcription Factors |
| Zdroj: | The FEBS Journal. 288:6112-6126 |
| ISSN: | 1742-4658 1742-464X |
| Popis: | Prostate cancer (PCa) is a very complex disease that is a major cause of death in men worldwide. Currently, PCa dependence on the androgen receptor (AR) has resulted in use of AR antagonists and anti-androgen therapies that reduce endogenous steroid hormone production. However, within two to three years of receiving first line androgen deprivation therapy, the majority of patients diagnosed with PCa progress to castration resistant prostate cancer (CRPC). There is an urgent need for therapies that are more durable than antagonism of the AR axis. Studies of Runt-related transcription factors (RUNX) and their heterodimerization partner, Core-Binding Factor Subunit b (CBFβ), are revealing that the RUNX family are drivers of CRPC. In this review, we describe what is presently understood about RUNX members in PCa, including what regulates and is regulated by RUNX proteins, and the role of RUNX proteins in the tumor microenvironment and AR signaling. We discuss the implications for therapeutically targeting RUNX, the potential for RUNX as PCa biomarkers, and the current pressing questions in the field. |
| Databáze: | OpenAIRE |
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