Inhibin B is a more sensitive marker of spermatogenetic damage than FSH in the irradiated non-human primate model
| Autor: | Stefan Schlatt, Luca Foppiani, G. F. Weinbauer, Eberhard Nieschlag, U Hacker-Klom, Manuela Simoni |
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| Rok vydání: | 1999 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors medicine.drug_class Endocrinology Diabetes and Metabolism Testicle Biology Follicle-stimulating hormone Endocrinology Germ cell proliferation Internal medicine Testis medicine Animals Testosterone Spermatogenesis Azoospermia Sperm Count Body Weight Prostatic Secretory Proteins Organ Size medicine.disease Sperm Spermatozoa not available Macaca fascicularis Radiation Injuries Experimental medicine.anatomical_structure Gonadotropin Follicle Stimulating Hormone Peptides hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | The Journal of endocrinology. 162(3) |
| ISSN: | 0022-0795 |
| Popis: | This study evaluated the effect of bilateral testicular irradiation (2 Gy) on reproductive hormones, testicular volume (TV) and sperm parameters in six adult cynomolgus monkeys. Hormone levels (FSH, inhibin B and testosterone (T)) were determined to find the most valuable endocrine marker of irradiation-induced damage. All parameters were analysed at weekly intervals for 14 weeks. Histological evaluation of both testes was performed at week 14 after irradiation when one monkey was castrated and at week 27 when the remaining five monkeys were bilaterally biopsied. A decrease in body weight, TV (30% of the pre-treatment size) and sperm count was observed after irradiation. Severe oligozoospermia was achieved throughout the study but azoospermia was recorded only occasionally. Histological evaluation revealed a heterogeneous picture with patchy arrangement of seminiferous tubules containing advanced germ cell types. An increase (P |
| Databáze: | OpenAIRE |
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