Role of biomarkers for early detection of ovarian cancer recurrence
| Autor: | Virginia Foreste, Giuseppe Di Iorio, Giuseppe Bifulco, Claudia Di Filippo, Pierluigi Giampaolino, Luigi Della Corte |
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| Přispěvatelé: | Giampaolino, P., Foreste, V., Della Corte, Luigi., Di Filippo, C., Iorio, G., Bifulco, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Early detection 03 medical and health sciences 0302 clinical medicine Antigen Cancer stem cell Ovarian cancer Recurrence Internal medicine microRNA medicine Mesothelin Osteopontin biology business.industry Biomarker medicine.disease 030104 developmental biology Folate receptor 030220 oncology & carcinogenesis biology.protein Surgery Review Article on Ovarian Cancer Recurrence business |
| Zdroj: | Gland Surg |
| Popis: | Ovarian cancer is frequently diagnosed at an advanced stage and a fraction of these patients fail to respond to primary therapy and relapses in 70% of cases. On account of the high recurrence probability and the poor outcomes after recurrence, there is an urgent need to predict progression as early as possible and thus found the strategies to detect and prevent a recurrence. Considering that biomarkers have contributed to the management of ovarian cancer by distinguishing benign and malignant pelvic masses and monitoring response to treatment, in this review, we aim to discuss the latest evidence reported in the literature about the use of biomarkers to detect OC recurrence. In detail, we summarized all the evidence of the most quoted biomarkers like HE4, osteopontin, mesothelin (MSLN), Folate receptor α (FOLR1), paraneoplastic antigens, miRNA, cancer stem cells (CSCs) and a combination of them to evaluate their role as prognostic biomarkers for ovarian cancer recurrence. |
| Databáze: | OpenAIRE |
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