Assessing PD-L1 Expression Level by Radiomic Features From PET/CT in Nonsmall Cell Lung Cancer Patients: An Initial Result
| Autor: | Xiuzhong Yao, Lisheng Wang, Yixian Guo, Mengmeng Jiang, Yinglong Guo, Jie Xiao, Dazhen Sun |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
PET-CT Lung Neoplasms Receiver operating characteristic business.industry Area under the curve B7-H1 Antigen Cross-validation 030218 nuclear medicine & medical imaging Clinical Practice 03 medical and health sciences 0302 clinical medicine ROC Curve Carcinoma Non-Small-Cell Lung Positron Emission Tomography Computed Tomography 030220 oncology & carcinogenesis medicine Humans Radiology Nuclear Medicine and imaging Pd l1 expression Radiology Non small cell Stage (cooking) business |
| Zdroj: | Academic Radiology. 27:171-179 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/j.acra.2019.04.016 |
| Popis: | Rationale and Objectives To explore the potential value of radiomic features-derived approach in assessing PD-L1 expression status in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods A cohort of 399 stage I–IV NSCLC patients were enrolled. Tumor segmentation was performed to select essential primary lesions of NSCLC cases after PET/CT images acquisition. Features were extracted, then filtered with automatic relevance determination and minimized with LASSO model based on its relevance of PD-L1 expression status. Finally, we built predictive models with features from the CT, the PET, and the PET/CT images, respectively, for differentiating different status of specific PD-L1 types. Five-fold cross validation was practiced to evaluate the signatures’ accuracy, and the receiver operating characteristic as well as the corresponding area under the curve (AUC) was reckoned for each model. Results With the total of 24 selected features which were significantly associated with PD-L1 expression levels, models based on CT-, PET-, PET/CT-derived features were built and compared. For PD-L1 (SP142) expression level over 1% prediction, models that comprised radiomic features from the CT, the PET, and the PET/CT images resulted in an AUC of 0.97, 0.61, and 0.97, respectively; models for over 50% prediction resulted with AUC of 0.80, 0.65, and 0.77. For PD-L1 (28-8) expression level prediction, predictive models of over 1% expression scored at 0.86, 0.62, and 0.85; and signatures of over 50% expression reached the score of AUCs at 0.91, 0.75, and 0.88, respectively. Conclusion The radiomic-based predictive approach, especially CT-derived predictive model, may anticipate PD-L1 expression status in NSCLC patients relatively accurate. It may be helpful in guiding immunotherapy in clinical practice and deserves further analysis. |
| Databáze: | OpenAIRE |
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