Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats
| Autor: | John J. Callaci, Frederick H. Wezeman, Ryan Himes, Dainius Juknelis |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Histology Bone density Physiology Endocrinology Diabetes and Metabolism Osteoporosis Alcohol abuse Collagen Type I Article Bone resorption Bone remodeling Rats Sprague-Dawley Bone Density Internal medicine Animals Medicine Bone Resorption Vitamin D Ibandronic Acid Bone mineral Diphosphonates business.industry medicine.disease Spine Rats Osteopenia medicine.anatomical_structure Endocrinology Alcohols Calcium Stress Mechanical business Cancellous bone |
| Zdroj: | Bone. 41:639-645 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2007.06.002 |
| Popis: | Decreased bone mass and bone strength can result from excess alcohol consumption in humans and alcohol treatment in the rat. Although the specific mechanism is unknown, the damaging effects of alcohol abuse modulate the bone remodeling cycle and increase bone turnover. Chronic alcohol consumption models have shown an inhibition of bone formation. We previously reported that binge alcohol treatment increases bone resorption and that alcohol-induced damage can be prevented by treatments with intermittent parathyroid hormone and bisphosphonates. In this study, we hypothesized that an effective dose of vitamin D (cholecalciferol) or a single dose of ibandronate would prevent bone loss caused by binge alcohol treatment in male rats. Forty-eight adult (450 gram) male Sprague-Dawley rats were randomly assigned to 6 treatment groups (n=8): (a) saline i.p., 3 days/week (C); (b) binge alcohol, 3 g/kg i.p., 3 days/week (A); (c) vitamin D, 5,000 IU/kg daily s.c. (D); (d) binge alcohol and vitamin D (AD); (e) ibandronate (120 microg, given as a single i.p. injection (I)); and (f) alcohol and ibandronate (AI) . After 4 weeks of treatment, proximal tibia and L3 and L4 vertebrae were analyzed for bone mineral density (BMD) by quantitative computerized tomography and compressive strength-to-failure using an Instron materials testing machine. Type I collagen cross-linked c-telopeptide, calcium, and 25-OH vitamin D levels were measured in serum collected at the time of sacrifice. Binge alcohol significantly decreased cancellous BMD by 58% in tibia and 23% in lumbar spine (p |
| Databáze: | OpenAIRE |
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