Reading difficulties in primary progressive aphasia in a regular language-speaking cohort of patients
| Autor: | María Nieves Cabrera-Martín, Jorge Matías-Guiu, José Luis Carreras, Jordi A. Matías-Guiu, Fernando Cuetos, María Valles-Salgado, Teresa Moreno-Ramos |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cognitive Neuroscience media_common.quotation_subject Semantic dementia Experimental and Cognitive Psychology Neuropsychological Tests 050105 experimental psychology Primary progressive aphasia Dyslexia 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Regular language Fluorodeoxyglucose F18 Phonetics Reading (process) medicine Humans 0501 psychology and cognitive sciences Prospective Studies media_common Aged Brain Mapping 05 social sciences Brain medicine.disease Spelling Semantics Feature (linguistics) Aphasia Primary Progressive Pattern Recognition Visual Reading Cohort Female Radiopharmaceuticals Psychology 030217 neurology & neurosurgery Orthography Cognitive psychology |
| Zdroj: | Neuropsychologia. 101 |
| ISSN: | 1873-3514 |
| Popis: | Reading impairment is an important feature in Primary Progressive Aphasia (PPA). The Spanish orthography entails completely regular spelling to sound correspondences, so reading disorders may be different to English. In the current study, reading, phonological and semantic abilities of 35 patients with the three variants of PPA, and 13 healthy volunteers were assessed. Brain metabolism was concomitantly obtained from each participant using 18F-fluorodeoxyglucose positron emission tomography imaging. Two main patterns of impairment were identified: difficulties in nonwords reading with preservation of exception words in agrammatic and logopenic aphasia, and the inverse pattern in semantic dementia. Left frontal and left parietotemporal regions were associated to nonwords reading, while the anterior temporal lobe was related to reading of exception words. These results support the usefulness of examining reading abilities in the differential diagnosis of PPA variants, and suggest potential types of words that could be used in Spanish to assess these patients. |
| Databáze: | OpenAIRE |
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