| Autor: |
Zhu, L, van der Pluijm, RW, Kucharski, M, Nayak, S, Tripathi, J, White, NJ, Day, NPJ, Faiz, A, Phyo, AP, Amaratunga, C, Lek, D, Ashley, EA, Nosten, F, Smithuis, F, Ginsburg, H, von Seidlein, L, Lin, K, Imwong, M, Chotivanich, K, Mayxay, M, Dhorda, M, Nguyen, HC, Nguyen, TNT, Miotto, O, Newton, PN, Jittamala, P, Tripura, R, Pukrittayakamee, S, Peto, TJ, Hien, TT, Dondorp, AM, Bozdech, Z |
| Přispěvatelé: |
Graduate School, Radiology and Nuclear Medicine, Intensive Care Medicine, AII - Infectious diseases, School of Biological Sciences |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Communications Biology, 5(1):274. Springer Nature |
| ISSN: |
2399-3642 |
| Popis: |
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. Ministry of Education (MOE) National Medical Research Council (NMRC) Published version This research was funded by Singapore National Medical Research Council grant #NMRC/OFIRG/0040/2017 and Singapore Ministry of education grant #MOE2019-T3-1-007 and #MOE2017-T2-2-030 (S) awarded to Z. Bozdech. Moreover, A.D. coordinated funding for the TRACII epidemiology studies funded by DFID (FCDO): Artemisinin Resistant Malaria Research Programme (TRAC). DFID PO 5408 and Wellcome Trust: MOP Thailand Core award 220211/Z/20/Z and 220211/A/20/Z. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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