Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient
| Autor: | Young Sil Kim, Chan Bok Chung, Kang Il Ko, Sun Hee Park, Ki Ho Kim, Young Heui Kim, Yong-Il Hwang, Jong-Heon Kim, Jin Guk Kim, Sang-Yong Eom |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Magnetic Resonance Spectroscopy Stereochemistry Enzyme-Linked Immunosorbent Assay Cosmetics Applied Microbiology and Biotechnology Biochemistry Plant Roots Collagen Type I Analytical Chemistry Placebos Ingredient Column chromatography Double-Blind Method Sanguisorba officinalis Humans Molecular Biology Cells Cultured DNA Primers Skin Active ingredient biology Traditional medicine Base Sequence Chemistry Plant Extracts Reverse Transcriptase Polymerase Chain Reaction Organic Chemistry Elastase General Medicine Free Radical Scavengers Middle Aged Saponins biology.organism_classification Skin Aging Officinalis Female Spectrophotometry Ultraviolet Matrix Metalloproteinase 1 Crystallization Cosmeceutical Type I collagen Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 72(2) |
| ISSN: | 1347-6947 |
| Popis: | In order to investigate the potential of a Sanguisorba officinalis root extract as an active ingredient for wrinkle-care cosmetics, we measured its free radical scavenging activity, elastase inhibitory activity, expression of MMP-1 (matrix metalloprotease-1) in vitro, and type I collagen synthesis in normal human fibroblast cells. To isolate the main components from the S. officinalis root extract, we purified the extract by solvent fractionation, column chromatography, and recrystallization. The active component was identified as ziyuglycoside I by a spectroscopic analysis. Ziyuglycoside I increased the expression of type I collagen in a dose-dependent manner (by up to 71.3% at 50 muM). A clinical study of a formulation containing ziyuglycoside I, which involved visual evaluation and image analysis, showed a significantly different effect (p |
| Databáze: | OpenAIRE |
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