Regulation of Gene Expression by Telomere Position Effect
| Autor: | Kyung-Ha Lee, Do-Yeon Kim, Wanil Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Review Biology Genome rearrangement telomere position effect Catalysis Telomere Position Effect Epigenesis Genetic Inorganic Chemistry Pathogenesis Neoplasms telomere looping Gene expression Animals Humans Epigenetics Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Regulation of gene expression telomere Organic Chemistry aging General Medicine Computer Science Applications Telomere Chromatin Cell biology Chemistry Gene Expression Regulation gene expression |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 12807, p 12807 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Many diseases that involve malignant tumors in the elderly affect the quality of human life; therefore, the relationship between aging and pathogenesis in geriatric diseases must be under-stood to develop appropriate treatments for these diseases. Recent reports have shown that epigenetic regulation caused by changes in the local chromatin structure plays an essential role in aging. This review provides an overview of the roles of telomere shortening on genomic structural changes during an age-dependent shift in gene expression. Telomere shortening is one of the most prominent events that is involved in cellular aging and it affects global gene expression through genome rearrangement. This review provides novel insights into the roles of telomere shortening in disease-affected cells during pathogenesis and suggests novel therapeutic approaches. |
| Databáze: | OpenAIRE |
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