Herparin and the stabilization of fibrin
| Autor: | B. J. Cuddigan |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
chemistry.chemical_element
Calcium Fibrin chemistry.chemical_compound medicine Humans Citrates Protamines Solubility Blood Coagulation Edetic Acid Multidisciplinary Chromatography biology Factor XIII Heparin Thrombin Substrate (chemistry) Fibrinogen Chromatography Ion Exchange chemistry biology.protein Urea medicine.drug |
| Zdroj: | Nature. 217(5130) |
| ISSN: | 0028-0836 |
| Popis: | IN experiments to compare the activity of factor XIII (fibrin stabilizing factor) in serum and plasma, it was necessary to activate the factor XIII in plasma by addition of calcium, but to prevent the plasma from clotting. Heparin was therefore used as an anti-coagulant. Addition of heparin to the test system resulted in the factor XIII deficient substrate clot being rendered insoluble in 5 M urea or 1 per cent monochloracetic acid (MCA) without addition of a source of factor XIII. An investigation of the effects of heparin on the solubility of fibrin in these reagents was therefore undertaken. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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