Calcipotriene/betamethasone dipropionate for the treatment of psoriasis vulgaris: an evidence-based review
| Autor: | Nupur U Patel, Kayla Felix, Steven R. Feldman, Danielle Reimer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
betamethasone diproprionate medicine.medical_treatment Betamethasone dipropionate vitamin D Review Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Psoriasis medicine Calcipotriol Combination Medication business.industry psoriasis medicine.disease Topical medication topical treatment chemistry calcipotriene 030220 oncology & carcinogenesis Calcipotriene business steroids Topical steroid medicine.drug Combination drug |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology |
| ISSN: | 1178-7015 |
| DOI: | 10.2147/ccid.s131727 |
| Popis: | While topical medications remain the cornerstone of the psoriasis treatment paradigm, they also come with the risk of multiple side effects. An alternative topical treatment option, calcipotriene or calcipotriol, is a vitamin D derivative that is thought to work by inhibiting keratinocyte proliferation and enhancing keratinocyte differentiation. Multiple studies have demonstrated its efficacy and safety in improving psoriasis when used in combination with topical corticosteroids. Given the effectiveness and side effect profile seen with this combination of topical steroid and calcipotriene, the US Food and Drug Administration approved a calcipotriene/betamethasone dipropionate product for use in psoriasis patients over the age of 12 in 2006. Our paper seeks to review clinical trial evidence of this combination medication and its use in the treatment of psoriasis vulgaris. While assessment of available evidence indicates that the topical medication is both safe and effective for the treatment of psoriasis vulgaris, addressing limitations of what is known, such as tolerability, adherence, and patient preference, of this combination drug in future high-impact studies is needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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