Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes
| Autor: | Rita de Cássia Pontello Rampazzo, Gregory A. Buck, Dayse T. Silva Neto, Samuel Goldenberg, Daniela Parada Pavoni, Luiz S. Ozaki, Maria de Nazareth Meirelles, M. Ruth Carvalho, Christian Probst, Mirian Claudia de Souza Pereira, Myrna G. Serrano, Marco Aurélio Krieger, Ping Xu, Patricio Manque, João M. P. Alves |
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| Rok vydání: | 2011 |
| Předmět: |
Chagas disease
Chagas Cardiomyopathy Cytoskeleton organization Trypanosoma cruzi Immunology Gene Expression Microbiology Host-Parasite Interactions Mice Immune system Immunity parasitic diseases medicine Animals Myocytes Cardiac Tropism In Situ Hybridization Host Response and Inflammation biology Errata Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Cell cycle biology.organism_classification medicine.disease Microarray Analysis Virology Infectious Diseases Parasitology Trypanosomiasis |
| Zdroj: | Infection and Immunity. 79:3471-3471 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Chagas' disease, caused by the hemoflagellate protozoan Trypanosoma cruzi , affects millions of people in South and Central America. Chronic chagasic cardiomyopathy, the most devastating manifestation of this disease, occurs in approximately one-third of infected individuals. Events associated with the parasite's tropism for and invasion of cardiomyocytes have been the focus of intense investigation in recent years. In the present study, we use murine microarrays to investigate the cellular response caused by invasion of primary murine cardiomyocytes by T. cruzi trypomastigotes. These studies identified 353 murine genes that were differentially expressed during the early stages of invasion and infection of these cells. Genes associated with the immune response, inflammation, cytoskeleton organization, cell-cell and cell-matrix interactions, apoptosis, cell cycle, and oxidative stress are among those affected during the infection. Our data indicate that T. cruzi induces broad modulations of the host cell machinery in ways that provide insight into how the parasite survives, replicates, and persists in the infected host and ultimately defines the clinical outcome of the infection. |
| Databáze: | OpenAIRE |
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