Cochlear Implantation in the Guinea Pig
| Autor: | Anne-Margarethe Kramer, Navid Ahmadi, Clemens Honeder, Chengjing Zhu, Christoph Arnoldner, Nodir Saidov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Speech perception Hearing loss Hearing Preservation medicine.medical_treatment General Chemical Engineering Guinea Pigs Audiology General Biochemistry Genetics and Molecular Biology Guinea Pig 03 medical and health sciences 0302 clinical medicine Animal model Issue 136 Cochlear implant medicine otorhinolaryngologic diseases Animals Humans Inner ear 030223 otorhinolaryngology Cochlear implantation Hearing Loss Hearing preservation General Immunology and Microbiology business.industry General Neuroscience Cochlear Implantation Cochlea Electrophysiology medicine.anatomical_structure Cochlear Implants Hearing range Models Animal Medicine Female sense organs Animal Model medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Visualized Experiments : JoVE |
| ISSN: | 1940-087X |
| Popis: | Cochlear implants are highly efficient devices that can restore hearing in subjects with profound hearing loss. Due to improved speech perception outcomes, candidacy criteria have been expanded over the last few decades. This includes patients with substantial residual hearing that benefit from electrical and acoustical stimulation of the same ear, which makes hearing preservation during cochlear implantation an important issue. Electrode impedances and the related issue of energy consumption is another major research field, as progress in this area could pave the way for fully implantable auditory prostheses. To address these issues in a systematic way, adequate animal models are essential. Therefore, the goal of this protocol is to provide an animal model of cochlear implantation, which can be used to address various research questions. Due to its large tympanic bulla, which allows easy surgical access to the inner ear, as well as its hearing range which is relatively similar to the hearing range of humans, the guinea pig is a commonly used species in auditory research. Cochlear implantation in the guinea pig is performed via a retroauricular approach. Through the bullostomy a cochleostomy is drilled and the cochlear implant electrode is inserted into the scala tympani. This electrode can then be used for electrical stimulation, determination of electrode impedances and the measurement of compound action potentials of the auditory nerve. In addition to these applications, cochlear implant electrodes can also be used as drug delivery devices, if a topical delivery of pharmaceutical agents to the cells or fluids of the inner ear is intended. |
| Databáze: | OpenAIRE |
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