Curative resection for lung cancer in octogenarians is justified
Autor: | Didier Schneiter, Monique Mosimann, Walter Weder, Wolfgang Jungraithmayr, Sven Hillinger, Nono Martucci, Michaela Tutic-Horn, Isabelle Opitz, Franco Gambazzi, Gaetano Rocco |
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Přispěvatelé: | University of Zurich, Jungraithmayr, Wolfgang |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty 10255 Clinic for Thoracic Surgery medicine.medical_treatment Population 610 Medicine & health 030204 cardiovascular system & hematology 03 medical and health sciences Pneumonectomy 0302 clinical medicine medicine Carcinoma education Lung cancer Survival rate education.field_of_study business.industry Perioperative medicine.disease Surgery 030228 respiratory system Cardiothoracic surgery 2740 Pulmonary and Respiratory Medicine Adenocarcinoma Original Article business |
Popis: | Background: Due to an increased life expectancy in a healthy aging population and a progressive incidence of lung cancer, curative pulmonary resections can be performed even in octogenarians. The present study aims to investigate whether surgery is justified in patients reaching the age of 80 years and older who undergo resection for non-small cell lung cancer (NSCLC). Methods: In this retrospective multi-centre analysis, the morbidity, mortality and long-term survival of 88 patients (24 females) aged ≥80 who underwent complete resection for lung cancer between 2000 and 2013 were analysed. Only fit patients with few comorbidities, low cardiopulmonary risk, good quality of life and a life expectancy of at least 5 years were included. Results: Curative resections from three thoracic surgery centres included 61 lobectomies, 9 bilobectomies, 6 pneumonectomies and 12 segmentectomies or wide wedge resections with additional systematic mediastinal lymphadenectomy in all cases. Final histology revealed squamous cell carcinoma [33], adenocarcinoma [41], large cell carcinoma [5] or other histological types [9]. Lung cancer stage distribution was 0 [1], I [53], II [17] and IIIA [14]. The overall 90-day mortality was 1.1%. The median hospitalisation and chest drainage times were 10 days (range, 5–27 days) and 5 days (range, 0–17 days), respectively. Thirty-six patients were complication-free (41%). In particular, pulmonary complications occurred in 25 patients (28%). In addition, 23 patients (26%) developed cardiovascular complications requiring medical intervention, while 24 patients (27%) had cerebrovascular complications, urinary tract infection and others. The median survival time was 51 months (range, 1–110 months), and the 5-year overall survival reached 45% without significance between tumour stages. Conclusions: Curative lung resections in selected octogenarians can be safely performed up to pneumonectomy for all tumour stages with a perioperative mortality, morbidity, and 5-year survival rate comparable to younger cohorts. |
Databáze: | OpenAIRE |
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