Impact of HIV infection on sustained virological response to treatment against hepatitis C virus with pegylated interferon plus ribavirin
| Autor: | María D. Merino, Nicolás Merchante, Purificación Cid, Juan Macías, Antonio Rivero, Patricia Monje-Agudo, Karin Neukam, Antonio Rivero-Juárez, F. Martínez-Marcos, Ángeles Castro-Iglesias, Juan A. Pineda, E. Ortega-González, Berta Pernas, Luis Miguel Real, Álvaro Mena |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Hepatitis C virus Population HIV Infections Hepacivirus medicine.disease_cause Gastroenterology Antiviral Agents Polyethylene Glycols chemistry.chemical_compound Pegylated interferon Internal medicine Genotype Ribavirin Medicine Humans Prospective Studies Prospective cohort study education education.field_of_study business.industry Coinfection Interferon-alpha virus diseases General Medicine Odds ratio Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Infectious Diseases Treatment Outcome chemistry Spain Immunology Drug Therapy Combination Female business medicine.drug |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname |
| Popis: | [Abstract] It is commonly accepted that human immunodeficiency (HIV) coinfection negatively impacts on the rates of sustained virological response (SVR) to therapy with pegylated interferon plus ribavirin (PR). However, this hypothesis is derived from comparing different studies. The aim of this study was to determine the impact of HIV coinfection on SVR to PR in one single population. In a multicentric, prospective study conducted between 2000 and 2013, all previously naïve hepatitis C virus (HCV)-infected patients who started PR in five Spanish hospitals were analyzed. SVR was evaluated 24 weeks after the scheduled end of therapy. Of the 1046 patients included in this study, 413 (39 %) were coinfected with HIV. Three hundred and forty-one (54 %) HCV-monoinfected versus 174 (42 %) HIV/HCV-coinfected patients achieved SVR (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|