Heterogeneity of insulin-dependent diabetes-new evidence
| Autor: | Timothy Dunsworth, N.E. Morton, Jose Barbosa, Stephen S. Rich |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Proband Genes Recessive Pedigree chart Human leukocyte antigen Biology HLA Antigens Genetic linkage Diabetes mellitus Genetics HLA-DR medicine Humans Allele Genetics (clinical) Recombination Genetic Models Genetic Histocompatibility Antigens Class II HLA-DR Antigens medicine.disease Pedigree Histocompatibility Diabetes Mellitus Type 1 HLA-B Antigens Female Disease Susceptibility Lod Score |
| Zdroj: | Clinical Genetics. 21:233-236 |
| ISSN: | 1399-0004 0009-9163 |
| Popis: | We have performed complex segregation and linkage analysis in 182 families with at least one insulin-dependent diabetic proband. All families were typed for B histocompatibility (HLA) antigens and 118 for DR. The recessive model fit the data best, with maximum likelihood estimates of recombination between HLA DR and the susceptibility factor of 0.019. Substantial heterogeneity was suggested, with smallest estimated recombination for pedigrees whose probands have two high-risk DR alleles. The results are compatible with a strong, tightly HLA-linked susceptibility factor and evidence for additional non-HLA linked genetic factor(s). |
| Databáze: | OpenAIRE |
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