Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity The Leiden Longevity Study
| Autor: | Anton J. M. de Craen, Rudi G. J. Westendorp, Jeroen van der Grond, P. Eline Slagboom, Irmhild Altmann-Schneider, Andrea B. Maier, Mark A. van Buchem |
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| Přispěvatelé: | Neuromechanics, AMS - Ageing and Morbidity |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Offspring brain Population Longevity Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine longevity SDG 3 - Good Health and Well-being Internal medicine medicine magnetic resonance imaging Humans Genetic Predisposition to Disease Longitudinal Studies education Stroke Aged Netherlands Advanced and Specialized Nursing Aged 80 and over education.field_of_study neuroimaging medicine.diagnostic_test business.industry cerebral small vessel disease aging Magnetic resonance imaging Odds ratio Middle Aged medicine.disease Hyperintensity Confidence interval Surgery Cerebral Small Vessel Diseases Cardiology Female Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Stroke; Vol 44 Stroke, 44(1), 9-14 Stroke, 44(1), 9-14. Lippincott Williams and Wilkins Altmann-Schneider, I, Van Der Grond, J, Slagboom, P E, Westendorp, R G J, Maier, A B, Van Buchem, M A & De Craen, A J M 2013, ' Lower susceptibility to cerebral small vessel disease in human familial longevity : The Leiden longevity study ', Stroke, vol. 44, no. 1, pp. 9-14 . https://doi.org/10.1161/STROKEAHA.112.671438 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/STROKEAHA.112.671438 |
| Popis: | Background and purpose— On MRI, cerebral white matter lesions, lacunar infarcts, and cerebral microbleeds are common imaging correlates of cerebral small vessel damage in apparently healthy elderly individuals. We investigated whether middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, have a lower prevalence of white matter lesions, lacunar infarcts, and cerebral microbleeds than control subjects. Methods— All subjects were from the Leiden Longevity Study. In this study, middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, were contrasted to their spouses. Cerebral small vessel disease was assessed using 3-T MRI. Results— Offspring were less likely to have severe periventricular frontal caps (odds ratio [OR], 0.3; 95% confidence interval [CI], 0.1–1.1; P trend=0.01) and severe periventricular bands (OR, 0.4; 95% CI, 0.2–0.8; P trend=0.02). Moreover, offspring were less likely to have frontal (OR, 0.4; 95% CI, 0.2–0.9; P trend=0.05), parietal (OR, 0.4; 95% CI, 0.1–0.9; P trend=0.001), temporal (OR, 0.3; 95% CI, 0.1–0.8]; P trend=0.004), and occipital subcortical white matter lesions (OR, 0.3; 95% CI, 0.1–0.6; P trend=0.001). Prevalence of lacunar infarcts also was lower in offspring (OR, 0.3; 95% CI, 0.1–1.1; P =0.07). Prevalence of microbleeds was not significantly different in offspring and control subjects. Conclusions— Exceptional familial longevity is associated with a lower susceptibility to white matter lesions and lacunar infarcts, but not cerebral microbleeds. |
| Databáze: | OpenAIRE |
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