Baculoviruses and nucleosome management
| Autor: | Loy E. Volkman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Insecta
Negatively-supercoiled ds DNA Genome Viral macromolecular substances Virus Replication Medical and Health Sciences INO80 chemistry.chemical_compound Transcription (biology) SWI/SNF INO80 TIP60 Virology Genetics Nucleosome Animals Topoisomerase 2 Viral Baculovirus Actin Cytochalasin D Genome biology Agricultural and Veterinary Sciences AcMNPV Biological Sciences Molecular biology SWI/SNF Actin-containing chromatin modification complexes Chromatin Cell biology Nucleosomes Histone chemistry Nucleosome mobilization Autographa californica M nucleopolyhedrovirus biology.protein Insect Proteins Viral chromatin TIP60 Baculoviridae DNA |
| Zdroj: | Volkman, LE. (2015). Baculoviruses and nucleosome management. Virology, 476, 257-263. doi: 10.1016/j.virol.2014.12.022. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5k84c651 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2014.12.022 |
| Popis: | © 2014 The Authors. Negatively-supercoiled-ds DNA molecules, including the genomes of baculoviruses, spontaneously wrap around cores of histones to form nucleosomes when present within eukaryotic nuclei. Hence, nucleosome management should be essential for baculovirus genome replication and temporal regulation of transcription, but this has not been documented. Nucleosome mobilization is the dominion of ATP-dependent chromatin-remodeling complexes. SWI/SNF and INO80, two of the best-studied complexes, as well as chromatin modifier TIP60, all contain actin as a subunit. Retrospective analysis of results of AcMNPV time course experiments wherein actin polymerization was blocked by cytochalasin D drug treatment implicate actin-containing chromatin modifying complexes in decatenating baculovirus genomes, shutting down host transcription, and regulating late and very late phases of viral transcription. Moreover, virus-mediated nuclear localization of actin early during infection may contribute to nucleosome management. |
| Databáze: | OpenAIRE |
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