Clinical evaluation of piperacillin with observations on penetrability into cerebrospinal fluid
| Autor: | Thomas A. Hoffman, D G Droller, R L Greenman, Gordon M. Dickinson |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Haemophilus Infections Continuous infusion Penicillins medicine.disease_cause Body weight Cerebrospinal fluid Humans Medicine Meningitis Pseudomonas Infections Pharmacology (medical) Adverse effect Piperacillin Pharmacology business.industry Pneumonia Pneumonia Pneumococcal medicine.disease Klebsiella Infections Surgery Infectious Diseases Superinfection Anesthesia business Clinical evaluation Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 20:481-486 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.20.4.481 |
| Popis: | Piperacillin, a new semisynthetic penicillin, was evaluated for efficacy and safety in 26 patients, most of whom had pneumonia. Included were four patients with gram-negative meningitis in whom the penetration of piperacillin into cerebrospinal fluid was determined. Cure was achieved in 11 of 17 patients with pneumonia; another 4 were improved. One relapse and one failure occurred among nine patients with gram-negative pneumonia. Cure or improvement occurred in seven of nine patients with gram-negative infection in various extrapulmonary sites. Piperacillin given by continuous infusion in a dosage ranging from 324 to 436 mg/kg of body weight per day to four patients with meningitis resulted in a mean cerebrospinal fluid level of 23 micrograms/ml at 24 h; the mean penetration of piperacillin into the cerebrospinal fluid was 32% at this interval. Levels of piperacillin in cerebrospinal fluid collected later during the course of therapy were also adequate. Adverse effects were noted in six patients, but only one episode of granulocytopenia was serious. Emergence of resistance to piperacillin did not occur, and only one superinfection was noted. Piperacillin appeared to be efficacious in the treatment of pneumonia. It penetrated well into the cerebrospinal fluid of patients with meningitis and may be useful for treatment of selected gram-negative infections in extrapulmonary sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|