A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma
| Autor: | Wei Cao, Canbang Peng, Zheqi Liu, Wenkai Zhou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Proportional hazards model Squamous Cell Carcinoma of Head and Neck General Medicine Nomogram Prognosis Clinical Practice stomatognathic diseases Otorhinolaryngology Head and Neck Neoplasms Internal medicine medicine Overall survival Carcinoma Squamous Cell Humans Basal cell Low body mass index Mouth Neoplasms Lymphocytes Low hemoglobin business Aged |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 279(1) |
| ISSN: | 1434-4726 |
| Popis: | The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients. Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes. Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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