The usefulness of trabecular bone score in patients with ankylosing spondylitis
Autor: | Tae-Hwan Kim, Yun Young Choi, Yoonah Song, Yongjin Sim, Seoung Wan Nam, Dam Kim, Yoon-Kyoung Sung, Soo-Kyung Cho |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
musculoskeletal diseases FRAX Osteoporosis bone 03 medical and health sciences 0302 clinical medicine Trabecular bone score Absorptiometry Photon Rheumatology Bone Density ankylosing spondylitis Medicine Humans In patient Spondylitis Ankylosing Bone mineral Ankylosing spondylitis Lumbar Vertebrae Receiver operating characteristic business.industry medicine.disease osteoporosis Cancellous Bone 030211 gastroenterology & hepatology Lumbar spine Original Article Female business Nuclear medicine |
Zdroj: | The Korean Journal of Internal Medicine, Vol 36, Iss 5, Pp 1211-1220 (2021) The Korean Journal of Internal Medicine |
ISSN: | 2005-6648 1226-3303 |
Popis: | Backgrounds/Aims: This study was performed to reveal the usefulness of the trabecular bone score (TBS) in assessing bone strength in patients with ankylosing spondylitis (AS) in comparison with dual-energy X-ray absorptiometry (DXA) methods.Methods: A total of 215 AS patients (75.8% male) were enrolled from a single university hospital in Korea. Demographic and clinical information were assessed. Patients completed X-rays of the cervical and lumbar spine (L-spine), and spinal ankyloses were quantified using the modified Stoke AS Spine Score (mSASSS). Hip, anteroposterior and lateral L-spine bone mineral density (BMD) and TBS were assessed by DXA methods. Clinical characteristics and bone strength measurement results were compared between male and female AS patients. The accuracy of each bone strength evaluation method in predicting Fracture Risk Assessment Tool (FRAX) scores indicating moderate or higher fracture risk was compared by receiver operating characteristic curves in patients aged ≥ 40 years. Correlations between each bone strength measurement method and mSASSS were examined.Results: Male patients showed higher mSASSS and less prevalent peripheral joint involvement compared to female patients (p < 0.05). TBS, hip BMD, and L-spine lateral BMD showed comparably high areas under the curve (AUCs) for predicting FRAX-major osteoporotic fractures (MOF) ≥ 10% (AUC ranged 0.72 to 0.76). TBS negatively correlated with mSASSS in both male and female patients (p < 0.01).Conclusions: TBS could predict the risk of MOF and is not influenced by spinal osteoproliferation in AS patients, even in those with advanced spinal changes. |
Databáze: | OpenAIRE |
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