The trypsin-induced leucostasis which leads to emphysema in the hamster is not due to contaminating endotoxins
| Autor: | B. Marie, P. Boerkmann, E. Reichart, C. Lambre, F. Plenat, F. Rogerieux |
|---|---|
| Přispěvatelé: | Institut National de l'Environnement Industriel et des Risques (INERIS) |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment LEUCOSTASIS Hamster EMPHYSEMA Granulocyte POLYMORPHONUCLEAR LEUCOCYTES TRYPSIN Pathology and Forensic Medicine Internal medicine medicine Saline Lung medicine.diagnostic_test business.industry Respiratory disease respiratory system Trypsin medicine.disease medicine.anatomical_structure Bronchoalveolar lavage Endocrinology [SDV.TOX]Life Sciences [q-bio]/Toxicology HAMSTER business Perfusion LUNG medicine.drug |
| Zdroj: | Journal of Pathology Journal of Pathology, Wiley, 1996, 178 (2), pp.215-220. ⟨10.1002/(sici)1096-9896(199602)178:23.0.co;2-k⟩ |
| ISSN: | 0022-3417 1096-9896 |
| DOI: | 10.1002/(sici)1096-9896(199602)178:23.0.co;2-k⟩ |
| Popis: | International audience; Intravenous injection of trypsin in the rat induces early lung leucostasis and emphysema of delayed onset. This report confirms that this emphysema is not rat-specific and that the leucostasis is not related to the presence of contaminating endotoxin in the trypsin. In hamsters (n=37), leucostasis did not occur when they were injected with heat-treated trypsin, but numerous granulocytes were sequestered in the vessels of hamsters receiving a fresh solution of trypsin. In these hamsters, the number of granulocytes harvested by lavage increased significantly (1-87 x 10⁶ per ml, .P |
| Databáze: | OpenAIRE |
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