Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion
| Autor: | Shawn G. Rhind, Doug Richards, Alex P. Di Battista, Nathan W. Churchill, Tom A. Schweizer, Michael G. Hutchison |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Critical Care and Emergency Medicine Traumatic Brain Injury Physiology Social Sciences Cardiovascular Analysis Matrix metalloproteinase Biochemistry Diagnostic Radiology 0302 clinical medicine Blood Flow Concussion Medicine and Health Sciences Psychology Trauma Medicine Cerebral Blood Flow Assay 0303 health sciences Multidisciplinary medicine.diagnostic_test Radiology and Imaging Brain Proteases Magnetic Resonance Imaging Sports Science Enzymes Body Fluids medicine.anatomical_structure Bioassays and Physiological Analysis Blood Cerebral blood flow Cerebrovascular Circulation Cardiology Medicine Female Anatomy Traumatic Injury circulatory and respiratory physiology Sports Research Article medicine.medical_specialty Adolescent Traumatic brain injury Imaging Techniques Science Central nervous system Neuroimaging Research and Analysis Methods 03 medical and health sciences Young Adult Diagnostic Medicine Internal medicine medicine Humans Sports and Exercise Medicine Acquired brain injury Brain Concussion 030304 developmental biology Behavior business.industry Biology and Life Sciences Proteins Magnetic resonance imaging medicine.disease Matrix Metalloproteinases Enzymology Metalloproteases Recreation Spin Labels business Neurotrauma 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 11 (2021) PLoS ONE, Vol 16, Iss 11, p e0253134 (2021) |
| ISSN: | 1932-6203 |
| Popis: | Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP) expression. In more severe forms of acquired brain injury, MMP up-regulation contributes to CBF impairments via increased blood-brain barrier permeability. A similar relationship is hypothesized for concussion, where recently concussed individuals with higher MMP levels have lower CBF. To test this hypothesis, 35 concussed athletes were assessed longitudinally at early symptomatic injury (median: 5 days post-injury) and at medical clearance (median: 24 days post-injury), along with 71 athletic controls. For all athletes, plasma MMPs were measured and arterial spin labelling was used to measure CBF. Consistent with our hypothesis, higher concentrations of MMP-2 and MMP-3 were correlated with lower global CBF. The correlations between MMPs and global CBF were also significantly diminished for concussed athletes at medical clearance and for athletic controls. These results indicate an inverse relationship between plasma MMP levels and CBF that is specific to the symptomatic phase of concussion. Analyses of regional CBF further showed that correlations with MMP levels exhibited some spatial specificity, with greatest effects in occipital, parietal and temporal lobes. These findings provide new insights into the mechanisms of post-concussion cerebrovascular dysfunction. |
| Databáze: | OpenAIRE |
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