IRIS II Study: Sensitivity and specificity of intact proinsulin, adiponectin, and the proinsulin/adiponectin ratio as markers for insulin resistance
| Autor: | Eberhard Standl, Hermann-Josef Strotmann, Sabine Pahler, Georg Lübben, Thomas Forst, Matthias R. Langenfeld, Peter H. Kann, Andreas Pfützner |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Disease duration Administration Oral Type 2 diabetes Models Biological Sensitivity and Specificity Endocrinology Insulin resistance Diabetes mellitus Internal medicine Odds Ratio Medicine Homeostasis Humans Hypoglycemic Agents Proinsulin Glycated Hemoglobin Adiponectin business.industry nutritional and metabolic diseases medicine.disease Medical Laboratory Technology Diabetes Mellitus Type 2 Intercellular Signaling Peptides and Proteins Hemoglobin Insulin Resistance business hormones hormone substitutes and hormone antagonists Biomarkers Diabetic Angiopathies |
| Zdroj: | Diabetes technologytherapeutics. 6(6) |
| ISSN: | 1520-9156 |
| Popis: | This study was performed to compare the specificity and sensitivity of intact proinsulin, adiponectin, and their ratio (proinsulin/adiponectin) in the prediction of insulin resistance as assessed by the homeostasis model assessment (HOMA) score (or =2 = resistant).Using a cross-sectional approach, 500 orally treated patients with type 2 diabetes (272 women, 238 men; mean +/- SD age, 64.8 +/- 11.6 years; hemoglobin A1c, 7.0 +/- 1.5%; disease duration, 5.8 +/- 6.1 years) were investigated. Various cutoffs for body mass index-adjusted adiponectin and proinsulin/adiponectin were compared with the established cutoff value of 10 pmol/L for fasting proinsulin.Fasting proinsulin correlated more closely with the HOMA score (r = 0.560, P0.001) than fasting adiponectin (r = -0.204, P0.001) or proinsulin/adiponectin (r = 0.355, P0.001). For proinsulin, specificity and sensitivity for insulin resistance in correlation to the HOMA score results were 96% and 70%, respectively. At a comparable specificity level to proinsulin, adiponectin did not reach a comparable sensitivity (14%), while the proinsulin/adiponectin ratio almost reached the same sensitivity (65%). Overall, patients with elevated proinsulin had a higher prevalence of micro- and macrovascular disease [odds ratio 1.47 (adiponectin, 1.08; proinsulin/ adiponectin, 1.48) and 1.34 (adiponectin, 1.32; proinsulin/adiponectin, 1.27), respectively].Elevation of fasting intact proinsulin seems to be the more specific marker for insulin resistance and increased cardiovascular risk than suppression of fasting adiponectin. Formation of the ratio does not lead to a further increase in the predictive value. |
| Databáze: | OpenAIRE |
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