Redistribution of body composition in patients with Graves’ disease after iodine-131 treatment
| Autor: | Liang-Jun Xie, Mu-Hua Cheng, Zhou Hj, Feng Zhang, Yi Chen, Feng-wei Zeng, Luping Qin, Jian-fang Li, Yuan Hj |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male China endocrine system medicine.medical_specialty endocrine system diseases Graves' disease Thyroid Gland Urology Medicine (miscellaneous) chemistry.chemical_element Muscle Development Iodine Hyperthyroidism Iodine Radioisotopes Absorptiometry Photon Hypothyroidism Bone Density hemic and lymphatic diseases medicine Humans Whole Body Imaging In patient Adiposity Bone Development Nutrition and Dietetics business.industry Upper body Thyroid Middle Aged medicine.disease Trunk Graves Disease medicine.anatomical_structure chemistry Body Composition Lean body mass Bone mineral content Female Radiopharmaceuticals business Follow-Up Studies |
| Zdroj: | European Journal of Clinical Nutrition. 69:856-861 |
| ISSN: | 1476-5640 0954-3007 |
| Popis: | The objective of this study was to investigate body composition redistribution at 3 months after radioactive iodine therapy (RAI).Eighty patients with Graves' disease (GD) for RAI and 18 volunteers were recruited. All patients underwent thyroid status test and dual-energy x-ray absorptiometry at baseline and 3 months after RAI. According to the second thyroid status test, patients were divided into the following groups: A, with aggravated hyperthyroidism; B-1, with improved hyperthyroidism; B-2, with euthyroidism; and B-3, with hypothyroidism.Total lean mass (LM) but fat mass (FM) and bone mineral content (BMC) of whole GD patients after RAI recovered to be not different with controls. Compared with baseline, in group A, FM in the left leg increased, and LM in left arm, right arm, trunk and total LM decreased (P0.05). In B-2, FM in the head increased, and LM in the head, right arm, trunk and total LM increased (P0.05). In B-3, FM in the right leg and total body fat percentage decreased, but FM in the head, android-to-gynoid fat ratio and body mass index increased (P0.05); LM of all sites, weight and total mass increased (P0.05); BMC in lumbar spine and left leg, and total BMC decreased (P0.05). Body composition of unmentioned sites was retained after RAI in each group (P0.05).Replenishment of LM gets priority rather than FM and BMC during the first 3 months after RAI, and the increase in LM starts from the upper body; head is the regional site in which FM recovery occurs first. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|