Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes
| Autor: | A. A. Basov, Ekaterina R. Vasilevskaya, L. V. Fedulova, S. S. Dzhimak |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
chemistry.chemical_element living systems Fractionation Chemical Fractionation Oxygen Article Analytical Chemistry nonradioactive isotopes 03 medical and health sciences 0302 clinical medicine Isotope fractionation neutron mitochondrial disorders Isotopes Computational chemistry Drug Discovery Atom Proton Therapy Animals Humans Neutron neurodegenerative diseases Physical and Theoretical Chemistry 030304 developmental biology Neutrons Organelles 0303 health sciences Isotope Organic Chemistry isotopic resonance Deuterium chemistry Chemical bond Models Chemical Chemistry (miscellaneous) electron density delocalization Molecular Medicine Protons 030217 neurology & neurosurgery isotopic discrimination |
| Zdroj: | Molecules Volume 24 Issue 22 |
| ISSN: | 1420-3049 |
| Popis: | This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with 18O/17O/16O, 15N/14N, 13C/12C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The comparative analysis of some experimental studies results revealed the following observation: &ldquo Isotopic shock&rdquo is highly probable and is observed mostly when chemical bonds form between atoms with a summary odd number of neutrons (i.e., bonds with a non-compensated neutron, which correspond to the following equation: Nn &minus Np = 2k + 1, where k ϵ Z, k is the integer, Z is the set of non-negative integers, Nn is number of neutrons, and Np is number of protons of each individual atom, or in pair of isotopes with a chemical bond). Data on the efficacy and metabolic pathways of the therapy also considered 2H-modified drinking and diet for some diseases, such as Alzheimer&rsquo s disease, Friedreich&rsquo s ataxia, mitochondrial disorders, diabetes, cerebral hypoxia, Parkinson&rsquo s disease, and brain cancer. |
| Databáze: | OpenAIRE |
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