Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
| Autor: | Sung Kyu Hong, Seok-Soo Byun, Hakmin Lee, Minseung Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology Multivariate analysis medicine.medical_treatment Cancer Treatment Kaplan-Meier Estimate Pathology and Laboratory Medicine Surgical pathology Prostate cancer Mathematical and Statistical Techniques 0302 clinical medicine Medicine and Health Sciences Reproductive System Procedures Multidisciplinary Prostatectomy Prostate Cancer Statistics Prostate Diseases Middle Aged Prognosis Radical Prostatectomy Treatment Outcome 030220 oncology & carcinogenesis Physical Sciences Medicine Anatomy Research Article Biochemical recurrence medicine.medical_specialty Clinical Pathology Urology Science Surgical and Invasive Medical Procedures Research and Analysis Methods 03 medical and health sciences Exocrine Glands Breast cancer Diagnostic Medicine Internal medicine medicine Humans Statistical Methods Propensity Score Aged Proportional Hazards Models Surgical Excision business.industry Proportional hazards model Prostatic Neoplasms Cancers and Neoplasms Biology and Life Sciences medicine.disease Genitourinary Tract Tumors Ki-67 Antigen 030104 developmental biology Anatomical Pathology Surgical Pathology Multivariate Analysis Propensity score matching Prostate Gland Neoplasm Recurrence Local business Mathematics |
| Zdroj: | PLoS ONE, Vol 14, Iss 11, p e0224671 (2019) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Ki-67 is known to be useful in estimating the fraction of proliferation tumor cells in various malignancies. We tried to investigate clinical association of Ki-67 (MIB-1) expression with the oncological outcomes in patients with localized prostate cancer (PCa) after the radical prostatectomy (RP). Materials and Methods We retrospectively analyzed the data of 1,561 patients who underwent RP for localized PCa. According to the propensity score having Ki-67 expression, 183 patients with positive Ki-67 expression were matched to 549 patients without Ki-67 expression. By using multivariate Cox-proportional hazards models and logistic regression tests, the prognostic value of each variable was tested. Results After propensity score matching, positive Ki-67 group showed significant worse clinical characteristics and pathologic outcomes than negative Ki-67 group. The multivariate analysis showed that the Ki-67 expression was significantly associated with several adverse pathologic outcomes including higher pathologic stage (p = 0.006), higher grade group (p = 0.005), seminal vesicle invasion (p = 0.036), and positive surgical margin (p = 0.025). The group with Ki-67 expression showed significant worse biochemical recurrence-free survival (p |
| Databáze: | OpenAIRE |
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