Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children
| Autor: | David Griffiths, Linda Diggle, Derrick W. Crook, E. Richard Moxon, Martin C. J. Maiden, Karen Sleeman, Sunetra Gupta, Tim E. A. Peto, Fiona Shackley |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Serotype
education.field_of_study Incidence (epidemiology) Attack rate Population Context (language use) Biology medicine.disease_cause medicine.disease Pneumococcal Infections United Kingdom Pneumococcal infections Infectious Diseases Carriage Streptococcus pneumoniae Immunology medicine Immunology and Allergy Humans Longitudinal Studies Serotyping education Child |
| Zdroj: | The Journal of infectious diseases. 194(5) |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background. The relative invasiveness rates (attack rates) of Streptococcus pneumoniae of different capsular serotypes in children are not known. Estimates of capsular serotype invasiveness (designated “invasive odds ratios”) that are based on cross-sectional prevalence carriage data have been published, but these estimates could be biased by variation in the duration of carriage. Methods. The relative attack rates of invasive pneumococci were measured using national UK surveillance data on invasive pneumococcal disease (IPD) incidence and data on incidence of pneumococcal acquisition from longitudinal studies of nasopharyngeal pneumococcal carriage. Results. We found significant differences in capsular serotype–specific attack rates. For example, capsular serotypes 4, 14, 7F, 9V, and 18C were associated with rates of 120 IPD cases/100,000 acquisitions, whereas capsular serotypes 23F, 6A, 19F, 16F, 6B, and 15B/C were associated with !10 IPD cases/100,000 acquisitions. There was an inverse relationship between duration of carriage and attack rate by capsular serotype ( ). Attack rates P ! .0001 were significantly correlated with invasive odds ratios ( ). P ! .0001 Conclusions. The capsular serotype is a major determinant of both pneumococcal duration of carriage and attack rate. Published invasive odds ratios are a reliable and practical method of determining capsular serotype invasiveness and will be valuable for investigating and characterizing emerging capsular serotypes in the context of conjugate vaccination. Streptococcus pneumoniae is a human-restricted bacterial commensal. Most, if not all, people acquire it at some time, and it usually colonizes the nasopharynx of individuals harmlessly. Of the pneumococci acquired by individuals, a few will go on to cause a spectrum of mild and severe diseases. Accumulatively, the diseases caused by pneumococci make it one of the leading causes of infectious diseases in people of all ages, but particularly in young children and the elderly. The prin |
| Databáze: | OpenAIRE |
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