Estrogen receptors and sex hormone binding globulin in neuronal cells and tissue
Autor: | Jack D. Caldwell, Konstantina Kalyvianaki, Gustav F. Jirikowski, V.M. Gebhart, Andrea Rodewald, Marilena Kampa |
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Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
medicine.drug_class Clinical Biochemistry Estrogen receptor 030209 endocrinology & metabolism Biochemistry Neuroprotection 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Internal medicine Sex Hormone-Binding Globulin medicine Estrogen Effects Animals Humans Molecular Biology Pharmacology Neurons biology business.industry Organic Chemistry Brain Rats Nerve growth factor Receptors Estrogen Estrogen Cell culture 030220 oncology & carcinogenesis Rat Pheochromocytoma biology.protein business hormones hormone substitutes and hormone antagonists |
Zdroj: | Steroids. 142 |
ISSN: | 1878-5867 |
Popis: | Estrogens exert a critical influence on neuronal tissues and cells. As demonstrated in many clinical studies, estrogens are neuroprotective to the extent that they improve prognosis for women with neurodegenerative diseases. Unfortunately, we still do not know exactly how these effects are mediated. Fifty years ago the first estrogen receptor was found, but since then many other new pathways of estrogen action have been identified. This review describes several of these pathways of estrogen effects and provides some conclusions and correlations about these as determined by recent studies with nerve growth factor differentiated rat pheochromocytoma cell line. |
Databáze: | OpenAIRE |
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