Conjugate and polysaccharide pneumococcal vaccines do not improve initial response of the polysaccharide vaccine in HIV-infected adults
| Autor: | Maria, Peñaranda, Antoni, Payeras, Ana, Cambra, Joan, Mila, Melcior, Riera, A, Villoslada |
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| Rok vydání: | 2010 |
| Předmět: |
Serotype
Adult Male Immunology HIV Infections Polysaccharide Vaccine Immunoglobulin G Pneumococcal Infections Pneumococcal Vaccines Immune system Immunology and Allergy Medicine Humans Avidity Vaccines Conjugate biology business.industry Virology Vaccination Infectious Diseases Immunization Pneumococcal vaccine biology.protein Female business |
| Zdroj: | AIDS (London, England). 24(8) |
| ISSN: | 1473-5571 |
| Popis: | This is a randomized trial to compare the immunoglobulin G response and the antibody avidity after two pneumococcal vaccinations, conjugated pneumococcal vaccine (CPV) and polysaccharide pneumococcal vaccine (PPV) 4 weeks after vs. PPV alone in 202 HIV-infected adults. There were no differences in the two strategies, either in the percentage of immunoglobulin G two-fold increase for the CPV included serotypes or immunoglobulin G two-fold increase, reaching the level of 1 microg/ml except for serotype 23F (26% responded after conjugated pneumococcal vaccine + PPV vs. 14% after PPV). No avidity increases were seen in any strategy. |
| Databáze: | OpenAIRE |
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