Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice
| Autor: | A. Gruzdev, Ladislav Dušek, Karel Souček, Michal Hofer, Zuzana Hoferová |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Mice 129 Strain Physiology Male mice Article 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences Basal (phylogenetics) Mice 0302 clinical medicine Internal medicine Radiation Ionizing medicine Deficient mouse Animals Mice Knockout biology business.industry Wild type General Medicine Hematopoiesis Radiation exposure Haematopoiesis Endocrinology Cyclooxygenase 2 030220 oncology & carcinogenesis biology.protein Cyclooxygenase business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1802-9973 |
| Popis: | We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of γ-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure. |
| Databáze: | OpenAIRE |
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