Histopathological and immunohistochemical features of proliferative lesions in the pituitary pars distalis of rats
| Autor: | Junko Sato, Takeshi Kanno, Takuya Doi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases Adenoma 040301 veterinary sciences Enteroendocrine cell carcinoma Biology Toxicology pituitary Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine Carcinoma rat Pituitary pars distalis Carcinogen Concise Review Pituitary tumors focal hyperplasia 04 agricultural and veterinary sciences medicine.disease Prolactin pars distalis 030220 oncology & carcinogenesis adenoma Immunohistochemistry hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.2020-0050 |
| Popis: | Pituitary proliferative lesions derived from the endocrine cells of the pars distalis are frequently encountered and adenomas/carcinomas are a common cause of death in standard 2-year carcinogenicity studies using various rat strains, especially Sprague-Dawley. This report describes the immunohistochemical characteristics of pituitary tumors derived from the pars distalis in rats. Prolactin (PRL)-containing tumors are the most common, with PRL/growth hormone (GH) dual positive tumor masses (PRL/GH co-positive tumor masses) being more prevalent than only PRL-positive tumor masses (PRL single-positive tumor masses). GH-containing tumors are relatively numerous and many of these are also PRL/GH co-positive tumor masses. TSH-containing tumors are common in females. PRL-containing tumors have been shown to increase the incidence of hyperlactation in males and mammary adenomas/adenocarcinomas in females, suggesting that these masses are functional tumors. |
| Databáze: | OpenAIRE |
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